Dual MAPK/CDK Targeting in Melanoma: New Approaches, New Challenges

New therapeutical approaches for the treatment of malignant Melanoma

Treatment for advanced melanoma: new drugs, new opportunities, new challenges.

The standard of care for the treatment of patients with metastatic melanoma has changed fundamentally based on two new treatment strategies that are, conceptually and biologically, largely independent: the blockade of immune regulatory molecules with monoclonal antibodies (termed “immune checkpoint blockade”) and the inhibition of BRAF V600 mutation–driven mitogen-activated protein kinase (MAPK...

Inm-2: New Approaches in Cryopreservation

Cryopreservation of embryos and gametes has become an indispensible service for infertility treatment. Vitrification is now a prevalent technique for cryopreservation in assisted reproductive technology (ART) replacing, in many cases, conventional slow cooling methodology. Fertility preservation in female patients has become a very topical issue. Various malignant and nonmalignant diseases have...

New Approaches in 3D Geomechanical Earth Modeling

In this paper two new approaches for building 3D Geomechanical Earth Model (GEM) were introduced. The first method is a hybrid of geostatistical estimators, Bayesian inference, Markov chain and Monte Carlo, which is called Model Based Geostatistics (MBG). It has utilized to achieve more accurate geomechanical model and condition the model and parameters of variogram. The second approach is the ...

New approaches in cancer immunotherapy: review article

Cancer immunotherapy refers to any intervention that leverages the immune system to eliminate a malignancy. Successful cancer immunotherapies generate an anti-cancer response that is systemic, specific, and durable and overcome to the primary limitations of traditional cancer treatment modalities. In this review paper, the effective methods in immune system to treat cancer, such as immunosuppre...